> For the complete documentation index, see [llms.txt](https://docs.biobox.io/guide/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.biobox.io/guide/how-to/ask-multi-modal-questions/ask-questions-with-natural-language-graphrag/use-agent-iris-to-converse-with-your-data.md). # Use Agent Iris to converse with your data To access Agent Iris, select "Ask a question" from the top right of the application tool bar. This will open the natural language chat dialog. Ask any question that you would like **using the terminology from your knowledge graph ontology**. This will return answers directly from the private data and and BioBox data packages you have injected into your knowledge graph.\ \ The conversation retains memory which allows you to ask follow up questions.\ A conversation with context can include questions such as * Which genes are upregulated in bulk RNAseq tumor samples pathologically confirmed to be endometrium adenocarcinoma? * Which of those genes are upregulated in fibroblast cells compared to epithelial cells of tumor samples pathologically confirmed to be endometrium adenocarcinoma? * Of the genes unregulated are any of the associated proteins upregulated in tumor samples pathologically confirmed to be endometrium adenocarcinoma? * Which biological processes are those genes involved in? * Are there any approved drugs targeting the proteins identified to be upregulated? {% embed url="" %}